Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils.

@article{Kindzelskii2002PregnancyAG,
  title={Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils.},
  author={Andrei L. Kindzelskii and J Huang and Tinnakorn Chaiworapongsa and Ryan M Fahmy and Yeon Kim and Roberto Romero and Howard R. Petty},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={110 12},
  pages={1801-11}
}
Pregnancy is associated with changes in host susceptibility to infections and inflammatory disease. We hypothesize that metabolic enzyme trafficking affects maternal neutrophil activation. Specifically, immunofluorescence microscopy has shown that glucose-6-phosphate dehydrogenase (G-6-PDase), the rate-controlling step of the hexose monophosphate shunt (HMS), is located near the cell periphery in control neutrophils but is found near the microtubule-organizing centers in cells from pregnant… CONTINUE READING