Pregnancy affects the pharmacokinetics of sildenafil and its metabolite in the rabbit.


1. There is growing interest in the use of sildenafil during pregnancy for various maternal and fetal conditions. This study aims to investigate the effect of pregnancy on the maternal pharmacokinetics (PK) of sildenafil and its main metabolite desmethylsildenafil in rabbits. Using NONMEM, population PK modeling was performed based on plasma samples from 31… (More)
DOI: 10.1080/00498254.2017.1422217


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