Pregnancy Outcomes in Kidney Transplant Recipients: A Systematic Review and Meta‐Analysis

@article{Deshpande2011PregnancyOI,
  title={Pregnancy Outcomes in Kidney Transplant Recipients: A Systematic Review and Meta‐Analysis},
  author={Neelam Deshpande and Nathan T. James and Lauren M. Kucirka and Brian J. Boyarsky and Jacqueline M. Garonzik-Wang and Robert A. Montgomery and Dorry L. Segev},
  journal={American Journal of Transplantation},
  year={2011},
  volume={11}
}
Approximately 50,000 women of reproductive age in the United States are currently living after kidney transplantation (KT), and another 2800 undergo KT each year. [] Key Method To obtain more generalizable inferences, we performed a systematic review and meta-analysis of articles published between 2000 and 2010 that reported pregnancy-related outcomes among KT recipients. Of 1343 unique studies, 50 met inclusion criteria, representing 4706 pregnancies in 3570 KT recipients. The overall post-KT live birth…
View on Wiley
ncbi.nlm.nih.gov
266 Citations
Highly Influential Citations
20
Background Citations
76
Methods Citations
9
Results Citations
12

266 Citations

Citation Type

Citation Type

Pregnancy outcomes of liver transplant recipients: A systematic review and meta‐analysis
  • N. Deshpande, N. James, +6 authors D. Segev
  • Medicine, Biology
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2012
TLDR
Although pregnancy after LT is feasible, the complication rates are relatively high and should be considered during patient counseling and clinical decision making.
Obstetric and long‐term kidney outcomes in renal transplant recipients: a 40‐yr single‐center study
TLDR
Pregnant women in the authors' center who have been pregnant between 1973 and 2013 had successful pregnancies with good long‐term transplant function and a pregnancy was not associated with poorer 10‐yr transplant or 20‐yr patient survival.
Pregnancy outcomes in women with kidney transplant: Metaanalysis and systematic review
TLDR
Although the outcome of live births is favorable, the risks of maternal and fetal complications are high in kidney transplant recipients and should be considered in patient counseling and clinical decision making.
Racial disparities and factors associated with pregnancy in kidney transplant recipients in the United States
TLDR
Hispanic race, younger age, and ESKD cause due to cystic disease or glomerulonephritis are significant factors associated with a higher likelihood of pregnancy in kidney transplant recipients.
Pregnancy outcomes in women with cardiothoracic transplants: A Systematic review and meta-analysis.
A Retrospective Analysis of Pregnancy Outcomes after Kidney Transplantation in a Single Center
TLDR
Pregnancy should be considered a high risk in renal transplant recipients, necessitating close follow-up, according to a single transplant center in a single facility from 1987 to 2011.
Outcomes of pregnancy in simultaneous pancreas and kidney transplant recipients: A single‐center retrospective study
TLDR
This is the largest published series of pregnancies in SPK recipients from a single center and a multidisciplinary approach by obstetric and transplant teams is important pre‐pregnancy, antenatally, and peripartum.
Pregnancy Outcomes for Kidney Transplant Recipients
TLDR
Although transplant pregnancies are generally successful, outcomes differ from the general population, indicating these remain high‐risk pregnancies despite good allograft function.
Timing of Pregnancy After Kidney Transplantation and Risk of Allograft Failure
TLDR
A higher incidence of allograft failure after pregnancy than previously reported is demonstrated and that the increased risk of allogsraft failure extends to pregnancies in the second posttransplant year.
Pregnancy in renal transplant recipients: a UK national cohort study.
TLDR
Most pregnancies in the United Kingdom in women with kidney transplants are successful but rates of maternal and neonatal complications remain high.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 84 REFERENCES
Pregnancy and maternal outcomes among kidney transplant recipients.
TLDR
Data confirm that a live birth in women with a functioning graft does not have an adverse impact on graft and patient survival and are confirmed that the absolute but not relative fertility rate fell during these four decades.
Impact of pregnancy on the outcome of kidney transplantation.
Outcome of 234 Pregnancies in 140 Renal Transplant Recipients From Five Middle Eastern Countries
TLDR
In the presence of good allograft function, the majority of pregnancies in renal transplant recipients have a good outcome but with increased incidence of preeclampsia, reduced gestational age, and low birth weights.
Pregnancy outcome after renal transplantation.
Pregnancy in renal transplant recipients: the Royal Free Hospital experience.
TLDR
Pregnancy appeared to have a deleterious effect on graft function in patients with SCr > 155 micro mol (1.75 mg/dl), and patients with pre-pregnancy SCr 200 micro mol/l are at greatest risk.
Pregnancy after renal transplantation: Experience in singapore general hospital
Pregnancy After Organ Transplantation: A Report From the U.K. Transplant Pregnancy Registry
TLDR
Pregnancy is likely to end in a live birth in a majority of organ transplant recipients, but in patients with greater prepregnancy serum creatinine (SCr) and/or drug-treated hypertension during pregnancy, subsequent renal function may be adversely affected.
Pregnancy after renal transplantation in Italian patients: focus on fetal outcome.
TLDR
In kidney transplant recipients who became pregnant and became pregnant the incidence of spontaneous abortion and preterm delivery was increased, and newborns delivered to these patients had low birth weight, but no congenital defects were noted and their development was normal.
Report from the National Transplantation Pregnancy Registry: outcomes of pregnancy after transplantation.
TLDR
It is incumbent upon transplant professionals to be aware of any additional risk to the fetus from immunosuppressive medications relative to the potential improvement in maternal graft function/survival conferred by each of these agents.
Pregnancy in kidney transplant recipients.
...
1
2
3
4
5
...