Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification

  title={Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification},
  author={Alan H Handyside and Eleni H. Kontogianni and K Hardy and Robert M. L. Winston},
OVER 200 recessive X chromosome-linked diseases, typically affecting only hemizygous males, have been identified. In many of these, prenatal diagnosis is possible by chorion villus sampling (CVS) or amniocentesis, followed by cytogenetic, biochemical or molecular analysis of the cells recovered from the conceptus. In others, the only alternative is to determine the sex of the fetus. If the fetus is affected by the defect or is male, abortion can be offered. Diagnosis of genetic defects in… Expand

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