Pregna-D′-pentaranes, progestins and antiprogestins: I. Separation of biological functions of steroid hormones

The synthesis, modification, structure, and biological activity in vivo of the 16α,17α- cycloalkanoprogesterone (pregna-D′-pentarane) analogues of progesterone are described. A possibility of separation of their biological functions has been demonstrated. A systematic synthesis of a set of uniform compounds that differ in a limited number of alterable… (More)