Pregna-D′-pentarane structure influences progesterone receptor affinity for DNA

@article{Shchelkunova2002PregnaDpentaraneSI,
  title={Pregna-D′-pentarane structure influences progesterone receptor affinity for DNA},
  author={T. A. Shchelkunova and P. Rubtsov and I. S. Levina and A. V. Kamerntsky and A. N. Smirnov},
  journal={Steroids},
  year={2002},
  volume={67},
  pages={323-332}
}
Electrophoretic mobility shift assay was used to determine whether pregna-D'-pentaranes allow progesterone receptor (PR) from rat uterine cytosol to bind hormone response element (HRE)-containing oligonucleotide duplexes and to measure the affinity of this interaction. The formation of DNA-protein complexes in low salt medium was progesterone-related ligand-, temperature-, and PR-dependent, and specific for HRE. The highest affinity of PR to DNA (equilibrium K(a) = 0.420 +/- 0.185 nM(-1)) was… Expand
Synthesis of 6,19-cyclopregnanes. Constrained analogues of steroid hormones.
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