Pregestational type 2 diabetes mellitus induces cardiac hypertrophy in the murine embryo through cardiac remodeling and fibrosis.

@article{Lin2017PregestationalT2,
  title={Pregestational type 2 diabetes mellitus induces cardiac hypertrophy in the murine embryo through cardiac remodeling and fibrosis.},
  author={Xue Lin and Penghua Yang and Edward Albert Reece and Peixin Yang},
  journal={American journal of obstetrics and gynecology},
  year={2017},
  volume={217 2},
  pages={
          216.e1-216.e13
        }
}
BACKGROUND Cardiac hypertrophy is highly prevalent in patients with type 2 diabetes mellitus. Experimental evidence has implied that pregnant women with type 2 diabetes mellitus and their children are at an increased risk of cardiovascular diseases. Our previous mouse model study revealed that maternal type 2 diabetes mellitus induces structural heart defects in their offspring. OBJECTIVE This study aims to determine whether maternal type 2 diabetes mellitus induces embryonic heart… CONTINUE READING
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