Pregestational maternal obesity impairs endocrine pancreas in male F1 and F2 progeny.

@article{GrausNunes2015PregestationalMO,
  title={Pregestational maternal obesity impairs endocrine pancreas in male F1 and F2 progeny.},
  author={Francielle Graus-Nunes and Eliete Dalla Corte Frantz and Wilian Rodrigues Lannes and Mariel Caroline da Silva Menezes and Carlos Alberto Mandarim-de-Lacerda and Vanessa Souza-Mello},
  journal={Nutrition},
  year={2015},
  volume={31 2},
  pages={380-7}
}
OBJECTIVE The aim of this study was to evaluate the effects of maternal obesity on pancreas structure and carbohydrate metabolism in early adult life, focusing on the F1 and F2 generations after F0 maternal pregestational, gestation, and lactation high-fat diet (HF). METHODS C57 BL/6 female mice (F0) were fed standard chow (SC) or an HF diet for 8 wk before mating and during the gestation and lactation periods to provide the F1 generation (F1-SC and F1-HF). At 3 mo old, F1 females were mated… CONTINUE READING