Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology.

@article{Bannister2011PregabalinSS,
  title={Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology.},
  author={Kirsty Bannister and Shafaq Sikandar and Claudia S. Bauer and Annette C Dolphin and F rank Porreca and Anthony Henry Dickenson},
  journal={Anesthesiology},
  year={2011},
  volume={115 1},
  pages={144-52}
}
BACKGROUND Opioid-induced hyperalgesia is recognized in the laboratory and the clinic, generating central hyperexcitability in the absence of peripheral pathology. We investigated pregabalin, indicated for neuropathic pain, and ondansetron, a drug that disrupts descending serotonergic processing in the central nervous system, on spinal neuronal hyperexcitability and visceral hypersensitivity in a rat model of opioid-induced hyperalgesia. METHODS Male Sprague-Dawley rats (180-200 g) were… CONTINUE READING