Pregabalin for the treatment of painful neuropathy.

  title={Pregabalin for the treatment of painful neuropathy.},
  author={Travis E Sonnett and Stephen M. Setter and Robert K. Campbell},
  journal={Expert review of neurotherapeutics},
  volume={6 11},
Pregabalin is an alpha(2)-delta ligand that binds to and modulates voltage-gated calcium channels, exerting its intended effect to reduce neuropathic pain. Pregabalin is the second of only two medications that are US FDA approved for the treatment of neuropathic pain associated with diabetic peripheral neuropathy; it is also the third medication for the treatment of postherpetic neuralgia. Currently, there are three pivotal clinical studies documenting the efficacy and safety of pregabalin for… CONTINUE READING

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