Pregabalin Antagonizes Copper-Induced Toxicity in the Brain: In vitro and in vivo Studies

@article{Marmolino2010PregabalinAC,
  title={Pregabalin Antagonizes Copper-Induced Toxicity in the Brain: In vitro and in vivo Studies},
  author={D. Marmolino and M. Manto},
  journal={Neurosignals},
  year={2010},
  volume={18},
  pages={210 - 222}
}
Background: Copper plays key roles in brain metabolism. Disorders of copper metabolism impact on neural signaling. The intracellular and extracellular concentrations of copper are tightly regulated. Pregabalin is a drug with multiple modes of action and has a high-affinity binding site for the alpha2delta subunit of voltage-gated calcium channels. Methods: Assessment of neuroprotective effects of pregabalin using cell culture, transcription studies, microdialysis and neurophysiological… Expand
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