Pregabalin: in the treatment of postherpetic neuralgia.

@article{McKeage2009PregabalinIT,
  title={Pregabalin: in the treatment of postherpetic neuralgia.},
  author={Kate McKeage and Susan J. Keam},
  journal={Drugs & aging},
  year={2009},
  volume={26 10},
  pages={
          883-92
        }
}
Pregabalin is the pharmacologically active S-enantiomer of 3-aminomethyl-5-methyl-hexanoic acid. It has a similar pharmacological profile to that of its developmental predecessor gabapentin, but had greater analgesic activity in rodent models of neuropathic pain. Pregabalin is thought to act by reducing the excessive release of several excitatory neurotransmitters by binding to the alpha(2)-delta protein subunit of voltage-gated calcium channels. Oral pregabalin 150-600 mg/day, administered in… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Herpes zoster.

  • The Medical clinics of North America
  • 2013
VIEW 12 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Neuropathic Pain and Sleep: A Review

  • Pain and Therapy
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

Management of the hospitalized patient experiencing acute on chronic pain: a case study.

  • Pain management nursing : official journal of the American Society of Pain Management Nurses
  • 2013
VIEW 1 EXCERPT
CITES BACKGROUND

Adjuvant analgesics in acute pain.

  • Expert opinion on pharmacotherapy
  • 2011
VIEW 1 EXCERPT
CITES BACKGROUND

Management of herpes zoster and post-herpetic neuralgia now and in the future.

  • Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2010
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Cost-effectiveness analysis of a lidocaine 5% medicated piaster compared with gabapentin and pregabahn for treating postherpetic neuralgia: a German perspective

H Liedgrens, N Hertel, A Gabriel
  • Clin Drug Invest
  • 2008

Pregabalin for postherpetic neuralgia: piacebo-controlied trial of fixed and fiexible dosing regimens on aiiodynia and time to onset of pain reiief

BR Stacey, JA Barrett, E Whalen, ai. et
  • J Pain
  • 2008

Cost-effectiveness analysis of pregabalin versus gabapentin in the managment of neuropathic pain due to diai:)etic poiyneuropathy or postherpetíc neuraigia

MJ Rodriguez, S Diaz, M Vera-Llonch
  • Curr Med Res Opin
  • 2007

Câ "" channel a25 ligands: novel modulators of neurotransmission

DJ Dooley, CP Taylor, S Donevan
  • Trends Pharmacol Sei
  • 2007