Pregabalin: in the treatment of postherpetic neuralgia.

@article{McKeage2009PregabalinIT,
  title={Pregabalin: in the treatment of postherpetic neuralgia.},
  author={K. McKeage and S. Keam},
  journal={Drugs & aging},
  year={2009},
  volume={26 10},
  pages={
          883-92
        }
}
Pregabalin is the pharmacologically active S-enantiomer of 3-aminomethyl-5-methyl-hexanoic acid. It has a similar pharmacological profile to that of its developmental predecessor gabapentin, but had greater analgesic activity in rodent models of neuropathic pain. Pregabalin is thought to act by reducing the excessive release of several excitatory neurotransmitters by binding to the alpha(2)-delta protein subunit of voltage-gated calcium channels. Oral pregabalin 150-600 mg/day, administered in… Expand
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