Pregabalin: A Review of its Use in Adults with Generalized Anxiety Disorder

@article{Frampton2014PregabalinAR,
  title={Pregabalin: A Review of its Use in Adults with Generalized Anxiety Disorder},
  author={J. Frampton},
  journal={CNS Drugs},
  year={2014},
  volume={28},
  pages={835-854}
}
Pregabalin (Lyrica®), a well established anxiolytic agent, has been approved in the EU for the treatment of generalized anxiety disorder (GAD) in adults. It has a distinct mechanism of action relative to other anti-anxiety agents (α2δ binding at presynaptic voltage dependent calcium channels leading to inhibition of excitatory neurotransmission), a rapid onset of effect (typically ≤1 week) and broad spectrum activity against both the psychic and somatic symptoms of GAD. In long-term studies… Expand
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References

SHOWING 1-10 OF 90 REFERENCES
Pregabalin for the treatment of generalized anxiety disorder: a novel pharmacologic intervention
TLDR
Randomized, controlled trials confirm that pregabalin is superior to placebo and comparable with lorazepam, alprazolam and venlafaxine for the treatment of patients with moderate-to-severe GAD. Expand
Pregabalin for the treatment of generalized anxiety disorder: an update
TLDR
The findings of randomized controlled trials and meta-analyses together indicate that pregabalin is efficacious in both acute treatment and relapse prevention in GAD, with some evidence of an early onset of effect, and broad efficacy in reducing the severity of psychological and physical symptoms of anxiety. Expand
Pharmacotherapy Update: Pregabalin in the Treatment of Generalized Anxiety Disorder
TLDR
Data is summarized showing that pregabalin has a significantly different safety profile from the benzodiazepines, SSRI/ SNRI anxiolytics, and SSRIs/SNRIs (eg, less gastrointestinal side effects and sexual dysfunction). Expand
Pharmacotherapy of generalized anxiety disorder: focus and update on pregabalin
TLDR
Evidence from available randomized placebo-controlled as well as head-to-head clinical trials with other drugs regarding its efficacy and safety in the GAD treatment is evaluated. Expand
Efficacy of pregabalin in depressive symptoms associated with generalized anxiety disorder: A pooled analysis of 6 studies
TLDR
Pregabalin, an alternative treatment option for GAD with a novel mechanism of action, also demonstrated efficacy in treating depressive symptoms typically encountered in GAD patients. Expand
Pregabalin: in the treatment of generalised anxiety disorder.
TLDR
Oral pregabalin, typically at dosages of 300-600 mg/day, was superior to placebo and similar to lorazepam, alprazolam and venlafaxine in improving anxiety and depressive symptoms in patients with moderate-to-severe generalised anxiety disorder (GAD). Expand
Efficacy and safety of pregabalin in elderly people with generalised anxiety disorder
TLDR
Pregabalin, in doses of 150–600 mg/day, was a safe and effective treatment of generalised anxiety disorder in patients 65 years and older and had an early onset and significantly improved both psychic and somatic symptoms of anxiety. Expand
Pregabalin: dose-response relationship in generalized anxiety disorder.
TLDR
Examination of the dose-response relationship for treatment of GAD with pregabalin found peak reduction in anxiety symptoms was observed to occur at a dose of approximately 450 mg/day, with a small reduction in treatment effect beyond this dose. Expand
Effects of pregabalin on sleep in generalized anxiety disorder.
TLDR
This review summarizes the results of clinical trials and pooled analyses that provide data on pregabalin's effect on sleep disturbance in patients diagnosed with GAD and suggests that improvement in sleep has been found to be associated with a reduction in daytime sleepiness. Expand
A Meta-Analysis of the Efficacy of Pregabalin in the Treatment of Generalized Anxiety Disorder
  • M. Boschen
  • Psychology, Medicine
  • Canadian journal of psychiatry. Revue canadienne de psychiatrie
  • 2011
TLDR
Pregabalin is an efficacious therapy for GAD, although effect sizes are smaller than those from earlier studies. Expand
...
1
2
3
4
5
...