Prefrontocortical serotonin depletion results in plastic changes of prefrontocortical pyramidal neurons, underlying a greater efficiency of short-term memory.

@article{PrezVega2000PrefrontocorticalSD,
  title={Prefrontocortical serotonin depletion results in plastic changes of prefrontocortical pyramidal neurons, underlying a greater efficiency of short-term memory.},
  author={Mar{\'i}a Isabel P{\'e}rez-Vega and Alfredo Ignacio Feria-Velasco and Ignacio Gonz{\'a}lez-Burgos},
  journal={Brain research bulletin},
  year={2000},
  volume={53 3},
  pages={291-300}
}
The prefrontal cortex activity is involved in organizing the short-term memory. Although the involvement of serotonin for an appropriate performance in learning and memory tests is well known, its role is still unclear; as is the cellular basis of short-term memory behavioral performance. Sprague-Dawley rats were stereotactically injected with 1 microg/microl of 5, 7-dihydroxitryptamine to cause a lesion to the dorsal raphe nucleus. Sham-operated or intact rats were also studied as control… CONTINUE READING

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