Prefrontocortical dopamine depletion induces antidepressant-like effects in rats and alters the profile of desipramine during Porsolt's test.

@article{Espejo1999PrefrontocorticalDD,
  title={Prefrontocortical dopamine depletion induces antidepressant-like effects in rats and alters the profile of desipramine during Porsolt's test.},
  author={Emilio Fdez Espejo and Francisco Javier Mi{\~n}ano},
  journal={Neuroscience},
  year={1999},
  volume={88 2},
  pages={609-15}
}
The objective of this study was to investigate whether bilateral dopamine depletion within the medial prefrontal cortex affects depression state, as well as the antidepressant efficacy of desipramine, in the forced swimming test. The rat's behaviour was evaluated by quantifying duration of immobility, climbing, swimming and diving. Immobility latency was also quantified and proved to be a suitable novel parameter. Monoamine levels within the medial prefrontal cortex were measured by high… CONTINUE READING

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