Prefrontal single-unit firing associated with deficient extinction in mice

@article{Fitzgerald2014PrefrontalSF,
  title={Prefrontal single-unit firing associated with deficient extinction in mice},
  author={Paul J. Fitzgerald and Nigel Whittle and Shaun M. Flynn and Carolyn M Graybeal and Andrew Holmes},
  journal={Neurobiology of Learning and Memory},
  year={2014},
  volume={113},
  pages={69-81}
}
The neural circuitry mediating fear extinction has been increasingly well studied and delineated. The rodent infralimbic subregion (IL) of the ventromedial prefrontal cortex (vmPFC) has been found to promote extinction, whereas the prelimbic cortex (PL) demonstrates an opposing, pro-fear, function. Studies employing in vivo electrophysiological recordings have observed that while increased IL single-unit firing and bursting predicts robust extinction retrieval, increased PL firing can correlate… CONTINUE READING

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