Prefrontal inputs to the amygdala instruct fear extinction memory formation

@inproceedings{Bukalo2015PrefrontalIT,
  title={Prefrontal inputs to the amygdala instruct fear extinction memory formation},
  author={Olena Bukalo and Courtney R. Pinard and Shana Silverstein and Christina Brehm and Nolan D. Hartley and Nigel Whittle and Giovanni Colacicco and Erica F Busch and Sachin Patel and Nicolas Singewald and Andrew J Holmes},
  booktitle={Science Advances},
  year={2015}
}
Persistent anxiety after a psychological trauma is a hallmark of many anxiety disorders. However, the neural circuits mediating the extinction of traumatic fear memories remain incompletely understood. We show that selective, in vivo stimulation of the ventromedial prefrontal cortex (vmPFC)–amygdala pathway facilitated extinction memory formation, but not retrieval. Conversely, silencing the vmPFC-amygdala pathway impaired extinction formation and reduced extinction-induced amygdala activity… CONTINUE READING
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