Prefrontal hypofunction in patients with intractable mesial temporal lobe epilepsy.

@article{Takaya2006PrefrontalHI,
  title={Prefrontal hypofunction in patients with intractable mesial temporal lobe epilepsy.},
  author={Shigetoshi Takaya and Takashi Hanakawa and Kazuo Hashikawa and Akio Ikeda and Nobukatsu Sawamoto and Takashi Nagamine and Koichi Ishizu and Hidenao Fukuyama},
  journal={Neurology},
  year={2006},
  volume={67 9},
  pages={
          1674-6
        }
}
We compared the cognitive functions and interictal cerebral glucose metabolism of 11 patients with mesial temporal lobe epilepsy (MTLE) with frequent seizures to those of 10 patients with MTLE with rare seizures; the groups were matched for age, sex, education, IQ, and focus side. The frequent-seizure group had more set-shifting impairment that correlated with glucose hypometabolism in the prefrontal cortices. Our results suggest that frequent seizures in MTLE are associated with hypofunction… CONTINUE READING

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