Prefrontal glucose metabolism in medication-resistant major depression.

BACKGROUND Medication-resistant depression (MRD) is associated with poorer attentional performance and immense socioeconomic costs. AIMS We aimed to investigate the central pathophysiology of MRD, previously linked to impaired prefrontal cortex function. METHOD A total of 54 participants (22 with MRD, 16 with non-resistant depression, 16 healthy… (More)