Prefrontal executive function associated coupling relates to Huntington's disease stage

@article{Unschuld2013PrefrontalEF,
  title={Prefrontal executive function associated coupling relates to Huntington's disease stage},
  author={P. G. Unschuld and Xinyang Liu and Megan Shanahan and Russell L. Margolis and Christopher A. Ross},
  journal={Cortex},
  year={2013},
  volume={49},
  pages={2661-2673}
}
Huntington's disease (HD) is a neurodegenerative disease caused by cytosine-adenine-guanine (CAG)-repeat expansion in the huntingtin (HTT) gene. Early changes that may precede clinical manifestation of movement disorder include executive dysfunction. The aim of this study was to identify functional network correlates of impaired higher cognitive functioning in relation to HD stage. Blood-oxygenation-level-dependent (BOLD) functional-magnetic resonance imaging (fMRI) and structural-MRI were… CONTINUE READING
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Problem solving, impulse control and planning in patients with early- and late-stage Huntington’s disease

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