Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance.

Abstract

Earlier studies with functional imaging in schizophrenia have demonstrated dysfunction of the dorsolateral prefrontal cortex during working memory. Controlling for behavioral performance and for catechol-O-methyltransferase (COMT) Val158Met genotype, we here demonstrate in a functional magnetic resonance imaging paradigm that patients recruit greater… (More)

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@article{Bertolino2006PrefrontalDI, title={Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance.}, author={Alessandro Bertolino and Grazia Caforio and Vittoria Petruzzella and Valeria K Latorre and Valeria Rubino and Savino Dimalta and Alessandra Torraco and Giuseppe Blasi and Roberto Quartesan and Venkata S. Mattay and Joseph H. Callicott and Daniel R. Weinberger and Tommaso Scarabino}, journal={Psychiatry research}, year={2006}, volume={147 2-3}, pages={221-6} }