Prefrontal dopamine D1 receptors and working memory in schizophrenia.

@article{AbiDargham2002PrefrontalDD,
  title={Prefrontal dopamine D1 receptors and working memory in schizophrenia.},
  author={Anissa Abi-Dargham and Osama Mawlawi and Ilise Lombardo and Roberto Gil and Diana Paola Sol{\'o}rzano Mart{\'i}nez and Yiyun Huang and Dah-Ren Hwang and John George Keilp and Lisa D. Kochan and Ronald L van Heertum and J. M. Gorman and Marc Laruelle},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 9},
  pages={
          3708-19
        }
}
Studies in nonhuman primates documented that appropriate stimulation of dopamine (DA) D1 receptors in the dorsolateral prefrontal cortex (DLPFC) is critical for working memory processing. The defective ability of patients with schizophrenia at working memory tasks is a core feature of this illness. It has been postulated that this impairment relates to a deficiency in mesocortical DA function. In this study, D1 receptor availability was measured with positron emission tomography and the… CONTINUE READING

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