Prefrontal cortical regulation of drug seeking in animal models of drug relapse.

@article{Lasseter2010PrefrontalCR,
  title={Prefrontal cortical regulation of drug seeking in animal models of drug relapse.},
  author={Heather C. Lasseter and Xiaohu Xie and Donna R. Ramirez and Rita A. Fuchs},
  journal={Current topics in behavioral neurosciences},
  year={2010},
  volume={3},
  pages={
          101-17
        }
}
Prefrontal cortical dysfunction is thought to underlie maladaptive behaviors displayed by chronic drug users, most notably the high propensity for relapse that severely impedes successful treatment of drug addiction. In animal models of drug relapse, exposure to drug-associated stimuli, small amounts of drug, and acute stressors powerfully reinstate drug seeking by critically engaging the prefrontal cortex, with the anterior cingulate, prelimbic, infralimbic, and orbitofrontal subregions making… CONTINUE READING
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