Prefrontal cortical inputs to the basal amygdala undergo pruning during late adolescence in the rat.

@article{Cressman2010PrefrontalCI,
  title={Prefrontal cortical inputs to the basal amygdala undergo pruning during late adolescence in the rat.},
  author={Victoria L Cressman and Jordan Balaban and Sara Steinfeld and Alexei Shemyakin and Peter H. Graham and Nelly Parisot and Holly Ann Moore},
  journal={The Journal of comparative neurology},
  year={2010},
  volume={518 14},
  pages={2693-709}
}
Transformations in affective and social behaviors, many of which involve amygdalar circuits, are hallmarks of adolescence in many mammalian species. In this study, using the rat as a model, we provide the first evidence that afferents of the basal amygdala (BA) undergo significant structural remodeling during adolescence. We used quantitative tract-tracing and gene expression profiling methods to characterize changes in the medial prefrontal cortical (mPFC) inputs to the BA across ages… CONTINUE READING

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