Prefrontal cortical-amygdalar metabolism in major depression.

  title={Prefrontal cortical-amygdalar metabolism in major depression.},
  author={Wayne C. Drevets},
  journal={Annals of the New York Academy of Sciences},
Functional neuroimaging studies of the anatomical correlates of familial major depressive disorder (MDD) and bipolar disorder (BD) have identified abnormalities of resting blood flow (BF) and glucose metabolism in depression in the amygdala and the orbital and medial prefrontal cortical (PFC) areas that are extensively connected with the amygdala. The amygdala metabolism in MDD and BD is positively correlated with both depression severity and "stressed" plasma cortisol concentrations measured… CONTINUE READING
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