Prefrontal cortex output circuits guide reward seeking through divergent cue encoding

  title={Prefrontal cortex output circuits guide reward seeking through divergent cue encoding},
  author={James M. Otis and Vijay Mohan K. Namboodiri and Ana M. Matan and Elisa S. Voets and Emily P. Mohorn and Oksana Kosyk and Jenna A. McHenry and James E Robinson and Shanna L Resendez and Mark A. Rossi and Garret D. Stuber},
The prefrontal cortex is a critical neuroanatomical hub for controlling motivated behaviours across mammalian species. In addition to intra-cortical connectivity, prefrontal projection neurons innervate subcortical structures that contribute to reward-seeking behaviours, such as the ventral striatum and midline thalamus. While connectivity among these structures contributes to appetitive behaviours, how projection-specific prefrontal neurons encode reward-relevant information to guide reward… CONTINUE READING


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