Prefrontal cortex modulates placebo analgesia

@article{Krummenacher2010PrefrontalCM,
  title={Prefrontal cortex modulates placebo analgesia},
  author={Peter Krummenacher and Victor Candia and Gerd Folkers and Manfred Schedlowski and Georg Sch{\"o}nb{\"a}chler},
  journal={PAIN®},
  year={2010},
  volume={148},
  pages={368-374}
}
Expectations and beliefs modulate the experience of pain, which is particularly evident in placebo analgesia. The dorsolateral prefrontal cortex (DLPFC) has been associated with pain regulation and with the generation, maintenance and manipulation of cognitive representations, consistent with its role in expectation. In a heat-pain paradigm, we employed non-invasive low-frequency repetitive transcranial magnetic stimulation (rTMS) to transiently disrupt left and right DLPFC function or used the… CONTINUE READING

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