Prefrontal cortex cognitive deficits in children treated early and continuously for PKU.

@article{Diamond1997PrefrontalCC,
  title={Prefrontal cortex cognitive deficits in children treated early and continuously for PKU.},
  author={Adele Diamond and Meredith B Prevor and Guy Callender and D P Druin},
  journal={Monographs of the Society for Research in Child Development},
  year={1997},
  volume={62 4},
  pages={i-v, 1-208}
}
To begin to study the importance of dopamine for executive function abilities dependent on prefrontal cortex during early childhood, the present investigation studied children in whom we predicted reduced dopamine in prefrontal cortex but otherwise normal brains. These are children treated early and continuously for the metabolic disorder phenylketonuria (PKU). Untreated PKU is the most common biochemical cause of mental retardation. The root problem is an inability to convert one amino acid… CONTINUE READING
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