Prefrontal cortex as the site of estrogen's effect on cognition.

  title={Prefrontal cortex as the site of estrogen's effect on cognition.},
  author={Patricia A Keenan and Waleed Ezzat and K Ginsburg and Gregory J. Moore},
  volume={26 6},
The hippocampus has long been presumed the primary site of action of estrogens on cognition; and explicit memory is considered the cognitive function most vulnerable to menopausal loss of estrogen. We hypothesize instead that the prefrontal cortex and its neural circuitry are prime mediators of estrogen's role in cognition. We also propose that previously reported menopausal cognitive decline, presumed to be hippocampally mediated, may be secondary to executive dysfunction. We used a cross… CONTINUE READING
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