Prefrontal cortex HCN1 channels enable intrinsic persistent neural firing and executive memory function.

@article{Thuault2013PrefrontalCH,
  title={Prefrontal cortex HCN1 channels enable intrinsic persistent neural firing and executive memory function.},
  author={S{\'e}bastien J. Thuault and Ga{\"e}l Malleret and Christine M. Constantinople and Russell E Nicholls and Irene Chen and Judy Zhu and Andrey A Panteleyev and Svetlana Vronskaya and Matthew F. Nolan and R. M. Bruno and Steven A. Siegelbaum and Eric R Kandel},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 34},
  pages={13583-99}
}
In many cortical neurons, HCN1 channels are the major contributors to Ih, the hyperpolarization-activated current, which regulates the intrinsic properties of neurons and shapes their integration of synaptic inputs, paces rhythmic activity, and regulates synaptic plasticity. Here, we examine the physiological role of Ih in deep layer pyramidal neurons in mouse prefrontal cortex (PFC), focusing on persistent activity, a form of sustained firing thought to be important for the behavioral function… CONTINUE READING

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