Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking

@article{Oever2008PrefrontalCA,
  title={Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking},
  author={Michel C. van den Oever and Natalia A. Goriounova and Ka Wan Li and Roel C. van der Schors and Rob Binnekade and Anton N M Schoffelmeer and Huibert D. Mansvelder and August B. Smit and Sabine Spijker and Taco J. de Vries},
  journal={Nature Neuroscience},
  year={2008},
  volume={11},
  pages={1053-1058}
}
Associative learning processes have an important role in the initiation and persistence of heroin-seeking. Here we show in a rat self-administration model that reexposure to cues previously associated with heroin results in downregulation of AMPA receptor subunit GluR2 and concomitant upregulation of clathrin-coat assembly protein AP2m1 in synaptic membranes of the medial prefrontal cortex (mPFC). Reduced AMPA receptor expression in synaptic membranes was associated with a decreased AMPA/NMDA… CONTINUE READING