Prefrontal control of the amygdala.

  title={Prefrontal control of the amygdala.},
  author={Ekaterina Likhtik and J. Guillaume Pelletier and Rony Paz and Denis Par{\'e}},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={25 32},
Accumulating evidence indicates that phobic and posttraumatic anxiety disorders likely result from a failure to extinguish fear memories. Extinction normally depends on a new learning that competes with the original fear memory and is driven by medial prefrontal cortex (mPFC) projections to the amygdala. Although mPFC stimulation was reported to inhibit the central medial (CEm) amygdala neurons that mediate fear responses via their brainstem and hypothalamic projections, it is unclear how this… CONTINUE READING
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