Prefrontal contributions to delayed spatial and object alternation: a positron emission tomography study.

@article{Zald2002PrefrontalCT,
  title={Prefrontal contributions to delayed spatial and object alternation: a positron emission tomography study.},
  author={David H. Zald and Clayton E. Curtis and Bradley S. Folley and Jos{\'e} V. Pardo},
  journal={Neuropsychology},
  year={2002},
  volume={16 2},
  pages={182-9}
}
Delayed alternation tasks are frequently used as probes of frontal lobe functioning. To clarify the neural substrates of delayed alternation performance in humans, the authors measured regional cerebral blood flow with H2(15)O positron emission tomography in healthy subjects as they performed delayed spatial and object alternation. Consistent with the monkey lesion literature, increased dorsolateral prefrontal activity emerged during delayed spatial alternation but not delayed object… CONTINUE READING

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