Prefrontal Regions Orchestrate Suppression of Emotional Memories via a Two-Phase Process

  title={Prefrontal Regions Orchestrate Suppression of Emotional Memories via a Two-Phase Process},
  author={Brendan Eliot Depue and Tim Curran and Marie T. Banich},
  pages={215 - 219}
Whether memories can be suppressed has been a controversial issue in psychology and cognitive neuroscience for decades. We found evidence that emotional memories are suppressed via two time-differentiated neural mechanisms: (i) an initial suppression by the right inferior frontal gyrus over regions supporting sensory components of the memory representation (visual cortex, thalamus), followed by (ii) right medial frontal gyrus control over regions supporting multimodal and emotional components… 
Inhibition of Action, Thought, and Emotion: A Selective Neurobiological Review.
  • D. Dillon, D. Pizzagalli
  • Psychology, Biology
    Applied & preventive psychology : journal of the American Association of Applied and Preventive Psychology
  • 2007
Memory consolidation reconfigures neural pathways involved in the suppression of emotional memories
It is reported that consolidated aversive memories retain their emotional reactivity and become more resistant to suppression after overnight consolidation, and possible neurobiological bases underlying the resistance to suppression of emotional memories in affective disorders are suggested.
Reduced Hippocampal-Cortical Connectivity During Memory Suppression Predicts the Ability to Forget Unwanted Memories
The findings suggest that systemic memory suppression involves more than the modulation of hippocampal activity—it alters functional connectivity patterns between the hippocampus and visual cortex, leading to successful forgetting.
Parallel Regulation of Memory and Emotion Supports the Suppression of Intrusive Memories
Evidence is reported in humans (males and females) that stopping episodic retrieval to suppress an unpleasant image triggers parallel inhibition of mnemonic and emotional content, supporting the broad principle that retrieval suppression is achieved by regulating hippocampal processes in tandem with domain-specific brain regions involved in reinstating specific content, in an activity-dependent fashion.
Neural Correlates of Direct and Indirect Suppression of Autobiographical Memories
The aim of the current study was to use fMRI to identify the neural mechanisms associated with the suppression of autobiographical memories and demonstrate successful forgetting effects in the no-think and memory substitution conditions.
Increased inhibition and enhancement of memory retrieval are associated with reduced hippocampal volume
It is shown that hippocampal volume is associated to changes in both enhancement and inhibitory processes of memory retrival, and its relationship to LPFC control over the hippocampus is examined.


Cognitive and neural mechanisms of emotional memory
  • S. Hamann
  • Psychology, Biology
    Trends in Cognitive Sciences
  • 2001
Neural Systems Underlying the Suppression of Unwanted Memories
Functional magnetic resonance imaging is used to identify the neural systems involved in keeping unwanted memories out of awareness and establish a neurobiological model for guiding inquiry into motivated forgetting.
Inhibition and the right inferior frontal cortex
Rethinking Feelings: An fMRI Study of the Cognitive Regulation of Emotion
Functional magnetic resonance imaging findings support the hypothesis that prefrontal cortex is involved in constructing reappraisal strategies that can modulate activity in multiple emotion-processing systems.
Right hemispheric dominance of inhibitory control: an event-related functional MRI study.
  • H. Garavan, T. Ross, E. Stein
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1999
Normal human behavior and cognition are reliant on a person's ability to inhibit inappropriate thoughts, impulses, and actions. The temporal and spatial advantages of event-related functional MRI
Neural Correlates of Conscious Self-Regulation of Emotion
Findings reinforce the view that emotional self-regulation is normally implemented by a neural circuit comprising various prefrontal regions and subcortical limbic structures and suggest that humans have the capacity to influence the electrochemical dynamics of their brains, by voluntarily changing the nature of the mind processes unfolding in the psychological space.
Suppression of Emotional and Nonemotional Content in Memory
Results for both verbal and nonverbal items indicated that the facilitatory and inhibitory influences of cognitive control were larger for negative than neutral items.
Prefrontal Set Activity Predicts Rule-Specific Neural Processing during Subsequent Cognitive Performance
It is argued that the prefrontal set activity does not reflect simple maintenance of the task rules but the process of implementing the rule for subsequent cognitive performance and that this is done through rule-selective interactions with areas involved in execution of the tasks.
Prefrontal Contributions to Executive Control: fMRI Evidence for Functional Distinctions within Lateral Prefrontal Cortex
Data suggest that anatomically separable subregions within lateral PFC may be functionally distinct and are consistent with models that posit a hierarchical relationship between dorsolateral and ventrolateral regions such that the former monitors and selects goal-relevant representations being maintained by the latter.