Prefrontal DA Transmission at D1 Receptors and the Pathology of Schizophrenia

  title={Prefrontal DA Transmission at D1 Receptors and the Pathology of Schizophrenia},
  author={Anissa Abi-Dargham and Holly M Moore},
  journal={The Neuroscientist},
  pages={404 - 416}
The current view on the dopamine (DA) hypothesis of schizophrenia postulates a cortical/subcortical imbalance: subcortical mesolimbic DA projections might be hyperactive, resulting in hyperstimulation of D2receptors and positive symptoms, whereas mesocortical DA projections to the prefrontal cortex might be hypoactive, resulting in hypostimulation of D1 receptors, negative symptoms, and cognitive impairment. Although the subcortical abnormalities are relatively well established now, the… 

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