Prefrontal Cortex

  title={Prefrontal Cortex},
  author={Joaqu{\'i}n M. Fuster},
  • J. Fuster
  • Published 3 October 2018
  • Psychology, Biology
The Prefrontal Cortex, Fifth Edition, provides users with a thoroughly updated version of this comprehensive work that has historically served as the classic reference on this part of the brain. The book offers a unifying, interdisciplinary perspective that is lacking in other volumes written about the frontal lobes, and is, once again, written by the award-winning author who discovered "memory cells," the physiological substrate of working memory. The fifth edition constitutes a comprehensive… 
A step forward in the understanding of prefrontal cortical functions
This special issue covers the reviews and reports by the speakers at the conference of PFC functions, and concludes that synaptic plasticity in the PFC is powerfully modulated by dopamine in an inverted-U-shaped, dose-dependent manner.
Morphological Correlations of Human and Monkey Frontal Lobe
In examining a complex process such as decision-making from a neural perspective, it may be beneficial to consider functional components in the context of cellular as well as connectional features of prefrontal areas.
Human Thought and the Lateral Prefrontal Cortex
An organizational view of the lateral prefrontal cortex is outlined which recognizes different lateral prefrontal subregions as functionally distinct and arranged in a rostrocaudal gradient of complexity in processing and representational abstraction, with higher abstraction in thought corresponding to more anterior lateral PFC regions.
Segregation of working memory functions within the dorsolateral prefrontal cortex
Findings in the monkey supporting a modular "domain-specific" model of PFC functional organization with respect to WM operations are described, which is composed of several subregions, based primarily on the nature of the information being processed in WM.
Emotion and the Prefrontal Cortex: An Integrative Review
A comprehensive review of functional neuroimaging, electrophysiological, lesion, and structural connectivity studies on the emotion-related functions of 8 subregions spanning the entire PFC is provided and the appraisal-by-content model is introduced, which provides a new framework for integrating the diverse range of empirical findings.
The prefrontal landscape: implications of functional architecture for understanding human mentation and the central executive.
  • P. Goldman-Rakic
  • Psychology, Biology
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1996
This paper focuses on the working memory processor as a specialization of prefrontal cortex and argues that the different areas within prefrontal cortex represent iterations of this function for different information domains, including spatial cognition, object cognition and additionally, in humans, semantic processing.
Executive Functions Brain Functional System
  • A. Ardila
  • Psychology, Biology
    Dysexecutive Syndromes
  • 2019
Executive functions are supported by a brain system involving the prefrontal and parietal areas, plus the anterior cingulate/supplementary motor area; it also includes some subcortical areas, in particular, the putamen and the thalamus.
Working Memory in the Prefrontal Cortex
Although further studies are needed to elucidate how the prefrontal cortex controls memory resource and supervises other systems, some important mechanisms related to the central executive have been identified.


The Frontal Granular Cortex and Behavior.
The papers collected in this monograph, the result of a symposium at the Pennsylvania State University in 1962, are of a high level of sophistication and provide a noteworthy contribution to the
Unit activity in prefrontal cortex during delayed-response performance: neuronal correlates of transient memory.
  • J. Fuster
  • Psychology, Biology
    Journal of neurophysiology
  • 1973
A previous investigation showed that bilateral or unilateral cooling of the pre-frontal cortical convexity produces marked and reversible deficits of performance in animals trained at the direct-method version of the delayed-response test, so the same test was adopted for the present study.
Cellular discharge in the dorsolateral prefrontal cortex of the monkey in cognitive tasks
Localization of function within the dorsolateral prefrontal cortex of the rhesus monkey.
Corticofugal projections to the brain stem.
From the results presented, it would seem that the ascending portion of the reticular system in the more caudal part of the brain stem exerts its effect upon the electrical activity of the cortex in a generalized manner, without evidence of topographic localization.
A search for the spatial engram within the frontal lobes of monkeys.
It is demonstrated that intact neural structures could assume some spatial functions after sequential destruction of sulcus principalis and monkeys with serial ablations demonstrated normal performance on a delayed-response task and on some place reversals, and partial recovery of delayed-alternation.
Brain and Intelligence: A Quantitative study of the frontal lobes
  • R. Livingston
  • Psychology
    The Yale Journal of Biology and Medicine
  • 1948
Each frontal lobe, which consists of the tissue in the cerebral hemisphere lying anterior to the fissure of Rolando, may be divided into three major fields: the motor and the premotor area, already