Preformulation and physicochemical interaction study of furosemide with different solid lipids

  title={Preformulation and physicochemical interaction study of furosemide with different solid lipids},
  author={H. Ali and S. Singh and P. Verma},
  journal={Journal of Pharmaceutical Investigation},
The aim of the present work was to prepare and characterize the matrices of Furosemide (FRSM) with different solid lipids (Compritol 888 ATO, Hydrokote C, Imwitor 491, Imwitor 372P, and Witepsol H12) using Fourier transform infrared (FTIR), Raman, differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy. The solubility of FRSM in various solid lipids followed the order of; Compritol 888 ATO > Witepsol H12 > Hydrokote C > Imwitor 491 > Imwitor 372. FTIR… Expand

Figures and Tables from this paper

Preparation and characterization of solid lipid nanoparticles of furosemide using quality by design
ABSTRACT The present work aimed to synthesize solid lipid nanoparticles (SLNs) of Furosemide (FRSM). The parameter sensitivity analysis showed a significant effect of particle size and referenceExpand
Screening and preparation of quercetin doped nanoemulsion: characterizations, antioxidant and anti-bacterial activities
Abstract The present study aims to prepare and characterize quercetin doped nanoemulsion (QTNE). On the basis of results of solubility, physicochemical interaction (FTIR, RAMAN, DSC-TGA and P-XRD)Expand
In vitro–in vivo and pharmacokinetic evaluation of solid lipid nanoparticles of furosemide using Gastroplus™
In this work, we conducted pharmacokinetic studies and established the in vitro and in vivo correlation (IVIVC) of furosemide (FRS) loaded solid lipid nanoparticles (FSLN). A bioanalytical methodExpand
DSC, FTIR and Raman Spectroscopy Coupled with Multivariate Analysis in a Study of Co-Crystals of Pharmaceutical Interest
This work verified to what extent a multivariate statistical approach such as principal component analysis (PCA) and cluster analysis (CA) can be used as a supporting tool for detecting co-crystal formation and revealed that the application of physical mixtures as reference samples allows a deeper insight into co- Crystallization than is possible with the use of API and co-former. Expand
Biological voyage of solid lipid nanoparticles: a proficient carrier in nanomedicine.
This review projects the prospects and issues faced by solid lipid nanoparticles (SLNs) in current scenarios, specially related to its clinical implementation and effectiveness. We re-examine theExpand
Principal component and cluster analyses as supporting tools for co-crystals detection
The application of chemometry as a solution to a range of problems in the pharmaceutical industry has been the subject of increasing interest in recent years. Therefore, the objective of this workExpand


Physicochemical characterization of solid dispersion of furosemide with TPGS.
The infrared spectroscopy and differential thermal analysis showed the physicochemical modifications of the furosemide from the solid dispersion, and a promising way to increase the solubility and dissolution rate of poorly soluble drugs. Expand
Release and diffusional modeling of metronidazole lipid matrices.
  • M. Ozyazici, E. Gökçe, G. Ertan
  • Medicine, Chemistry
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2006
It was found that Beeswax has a very close drug release rate with the target profile of metronidazole, and swelling and relaxation properties of lipid matrices should be examined together for a correct evaluation on drug diffusion mechanism of insoluble matrices. Expand
Improving furosemide polymorphs properties through supramolecular complexes of β-cyclodextrin.
It was observed that the binary complex significantly increased the solubility of furosemide form I in the gastric simulated fluid, which resulted in a rise in the bioavailability of this formulation after oral administration. Expand
Physicochemical characterization of furosemide modifications
Abstract The polymorphism of furosemide has been extensively investigated and characterized using X-ray powder diffractometry, differential scanning calorimetry, infrared and Fourier transformExpand
Selection and characterization of suitable lipid excipients for use in the manufacture of didanosine-loaded solid lipid nanoparticles and nanostructured lipid carriers.
The crystalline state and polymorphism of lipids with the best-solubulizing potential for DDI was investigated and a mixture of Precirol® ATO 5 and Transcutol® HP may be used to manufacture DDI-loaded SLN and NLC, respectively. Expand
Novel furosemide cocrystals and selection of high solubility drug forms.
Furosemide was screened in cocrystallization experiments with pharmaceutically acceptable coformer molecules to discover cocrystals of improved physicochemical properties, that is high solubility and good stability, that are identified in a solid form screen. Expand
Glibenclamide-loaded self-nanoemulsifying drug delivery system: development and characterization
The results of this study indicate that the self-nanoemulsifying drug delivery system of GBD, owing to nanosize, has potential to enhance its absorption and without interaction or incompatibility between the ingredients. Expand
Compatibility study between ketoprofen and pharmaceutical excipients used in solid dosage forms.
A possible interaction was found between the KT with polyvinylpyrrolidone K30 and magnesium stearate, which could influence the stability of the KT in the binary mixtures. Expand
Correlation between long-term stability of solid lipid nanoparticles (SLN) and crystallinity of the lipid phase.
  • C. Freitas, R. Müller
  • Chemistry, Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 1999
Stabilization of physically critical SLN dispersions seems possible by inhibition of the transformation of the lipid to the stable modification to cause a distinct increase in the recrystallization index. Expand
Applications of supercritical fluids to enhance the dissolution behaviors of Furosemide by generation of microparticles and solid dispersions.
  • Nicola De Zordi, M. Moneghini, +4 authors M. Bolger
  • Chemistry, Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2012
The in vitro bioavailability improvement of Furosemide through particle size reduction as well as formation of solid dispersions (SDs) using the hydrophilic polymer Crospovidone is reported upon. Expand