Preformulation Stability Studies of the New Dipeptide Angiotensin-Converting Enzyme Inhibitor RS-10029

Abstract

The degradation kinetics, products, and mechanisms of RS-10029 (2), 2-[2-[(l-carboxylic acid)-3-phenylpropyl]amino-l-oxopropyl] 6,7-dimethoxy- 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (S,S,S), in aqueous solutions from pH 1 to pH 13 were studied at 50, 60, and 80°C. Pseudo-first-order kinetics were obtained throughout the entire pH range studied… (More)
DOI: 10.1023/A:1015984617472

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Cite this paper

@article{Gu1988PreformulationSS, title={Preformulation Stability Studies of the New Dipeptide Angiotensin-Converting Enzyme Inhibitor RS-10029}, author={Leo C. Gu and Robert G. Strickley}, journal={Pharmaceutical Research}, year={1988}, volume={5}, pages={765-771} }