Preformed protein-binding motifs in 7SK snRNA: structural and thermodynamic comparisons with retroviral TAR.

@article{Durney2010PreformedPM,
  title={Preformed protein-binding motifs in 7SK snRNA: structural and thermodynamic comparisons with retroviral TAR.},
  author={Michael A. Durney and Victoria M. D'Souza},
  journal={Journal of molecular biology},
  year={2010},
  volume={404 4},
  pages={555-67}
}
The 7SK small nuclear RNA is a highly conserved non-coding RNA that regulates transcriptional elongation. 7SK utilizes the HEXIM proteins to sequester the transcription factor P-TEFb by a mechanism similar to that used by retroviral TAR RNA to engage Tat and P-TEFb. Tat has also recently been shown to bind 7SK directly and recruit P-TEFb to TAR. We report here the solution structures of the free and arginine-bound forms of stem loop 4 of 7SK (7SK-SL4). Comparison of the 7SK-SL4 and TAR… CONTINUE READING
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