Preformed CD40 ligand exists in secretory lysosomes in effector and memory CD4+ T cells and is quickly expressed on the cell surface in an antigen-specific manner.

@article{Koguchi2007PreformedCL,
  title={Preformed CD40 ligand exists in secretory lysosomes in effector and memory CD4+ T cells and is quickly expressed on the cell surface in an antigen-specific manner.},
  author={Yoshinobu Koguchi and Timothy J Thauland and Mark K. Slifka and David C Parker},
  journal={Blood},
  year={2007},
  volume={110 7},
  pages={
          2520-7
        }
}
CD40 ligand (CD40L) is an essential effector cytokine for macrophage activation, dendritic cell licensing, and T-cell-dependent antibody responses. Although CD40L is known to be made de novo following antigen recognition, several reports have described surface mobilization of preformed, intracellular CD40L in certain CD4(+) effector T cells. Here we show that rapid surface expression of preformed CD40L following antigen recognition is a general property of both effector and memory CD4(+) T… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 41 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

Similar Papers

Loading similar papers…