Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation.

@article{Zhang2016PrefoldinAP,
  title={Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation.},
  author={Yingjie Zhang and Madhulika Rai and Cheng Wang and Cayetano Gonzalez and Hongyan Wang},
  journal={Scientific reports},
  year={2016},
  volume={6},
  pages={23735}
}
Prefoldin is a molecular chaperone complex that regulates tubulin function in mitosis. Here, we show that Prefoldin depletion results in disruption of neuroblast polarity, leading to neuroblast overgrowth in Drosophila larval brains. Interestingly, co-depletion of Prefoldin and Partner of Inscuteable (Pins) leads to the formation of gigantic brains with severe neuroblast overgrowth, despite that Pins depletion alone results in smaller brains with partially disrupted neuroblast polarity. We show… CONTINUE READING