Preferred conformation of the tert-butoxycarbonyl-amino group in peptides.

  title={Preferred conformation of the tert-butoxycarbonyl-amino group in peptides.},
  author={E. Benedetti and Carlo Pedone and C. Toniolo and G N{\'e}methy and Marcia S. Pottle and Harold A. Scheraga},
  journal={International journal of peptide and protein research},
  volume={16 2},
Structural parameters, derived from X-ray crystallographic data, have been compiled for amino acid and linear peptide derivatives which contain the N-terminal tert-butoxycarbonyl (Boc) group or its next higher homolog, the tert-amyloxycarbonyl group. The comparison of the geometry of the urethane group in Boc-derivatives with that of the peptide group shows small differences in bond angles about the trigonal carbon, because of altered interactions when a C alpha H group of a peptide unti is… CONTINUE READING