Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life.

@article{Schroeder1990PreferentialUO,
  title={Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life.},
  author={Harry W. Schroeder and Judy Y Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 16},
  pages={
          6146-50
        }
}
The ability to respond to specific antigens develops in a programmed fashion. Although the antibody repertoire in adults is presumably generated by stochastic combinatorial joining of rearranged heavy variable, diversity, and joining (VH-DH-JH) and light (VL-JL) chains, experimental evidence in the mouse has shown nonrandom utilization of variable gene segments during ontogeny and in response to specific antigens. In this study, we have performed sequence analysis of 104-day human fetal liver… CONTINUE READING

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 74 CITATIONS, ESTIMATED 80% COVERAGE

Diversification, not use, of the immunoglobulin VH gene repertoire is restricted in DiGeorge syndrome

  • The Journal of experimental medicine
  • 1993
VIEW 10 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Survival of the fetus: fetal B and T cell receptor repertoire development

  • Seminars in Immunopathology
  • 2017
VIEW 3 EXCERPTS
CITES BACKGROUND

FILTER CITATIONS BY YEAR

1991
2018

CITATION STATISTICS

  • 3 Highly Influenced Citations

Similar Papers