Preferential suppression of delayed-type hypersensitivity by L-156,602, a C5a receptor antagonist.

@article{Tsuji1992PreferentialSO,
  title={Preferential suppression of delayed-type hypersensitivity by L-156,602, a C5a receptor antagonist.},
  author={Ryohei F. Tsuji and Masakazu Uramoto and Hiroyuki Koshino and Noriko M. Tsuji and Junji Magae and Kazuo Nagai and Masao Yamasaki},
  journal={Bioscience, biotechnology, and biochemistry},
  year={1992},
  volume={56 10},
  pages={1686-9}
}
In the course of our screening for in vivo immunomodulating substances in which sheep red blood cells (SRBC) and heat-killed Brucella abortus cells (thymus dependent and independent antigens, respectively) for antibody production assays, and trinitrobenzene sulfonic acid (TNBS) for delayed-type hypersensitivity (DTH) assay were adopted as antigens, we detected a DTH-specific suppressive activity. The producing organism was isolated from a soil sample collected in Ushiku City, Ibaraki, Japan and… CONTINUE READING