Preferential sphingosine-1-phosphate enrichment and sphingomyelin depletion are key features of small dense HDL3 particles: relevance to antiapoptotic and antioxidative activities.

@article{Kontush2007PreferentialSE,
  title={Preferential sphingosine-1-phosphate enrichment and sphingomyelin depletion are key features of small dense HDL3 particles: relevance to antiapoptotic and antioxidative activities.},
  author={Anatol Kontush and Patrice Th{\'e}rond and Amal Zerrad and Martine Couturier and Anne N{\`e}gre-Salvayre and Juliana A de Souza and Sandrine Chantepie and M. John Chapman},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 8},
  pages={1843-9}
}
OBJECTIVE The purpose of this study was to define heterogeneity in the molecular profile of lipids, including sphingomyelin and sphingosine-1-phosphate, among physicochemically-defined HDL subpopulations and potential relevance to antiatherogenic biological activities of dense HDL3. METHODS AND RESULTS The molecular profile of lipids (cholesteryl esters, phospholipids, sphingomyelin, and sphingosine-1-phosphate) in physicochemically-defined normolipidemic HDL subpopulations was determined by… CONTINUE READING

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