Preferential selection of human T-cell leukemia virus type I provirus integration sites in leukemic versus carrier states.

@article{Doi2005PreferentialSO,
  title={Preferential selection of human T-cell leukemia virus type I provirus integration sites in leukemic versus carrier states.},
  author={Keitarou Doi and Xiaolin Wu and Yuko Taniguchi and Jun-Ichirou Yasunaga and Yorifumi Satou and Akihiko Okayama and Kisato Nosaka and Masao Matsuoka},
  journal={Blood},
  year={2005},
  volume={106 3},
  pages={1048-53}
}
Human T-cell leukemia virus type I (HTLV-I) is a causative agent of neoplastic disease, adult T-cell leukemia (ATL). Although the encoding viral proteins play an important role in oncogenesis, the role of the HTLV-I proviral integration site remains unsolved. We determined the integration sites of HTLV-I proviruses in ATL cells and HTLV-I-infected cells in asymptomatic carriers. In carrier and ATL cells, HTLV-I provirus was integrated into the transcriptional unit at frequencies of 26.8% (15/56… CONTINUE READING
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