Preferential response of cancer cells to zebularine.

@article{Cheng2004PreferentialRO,
  title={Preferential response of cancer cells to zebularine.},
  author={Jonathan C. Cheng and Christine Bora Yoo and Daniel J. Weisenberger and Jody Chouying Chuang and Chandra Wozniak and Gangning Liang and Victor E. Marquez and Sheldon B. Greer and Torben Falck Orntoft and Thomas Thykjaer and Peter A. Jones},
  journal={Cancer cell},
  year={2004},
  volume={6 2},
  pages={
          151-8
        }
}
The frequent silencing of tumor suppressor genes by altered cytosine methylation and chromatin structural changes makes this process an attractive target for epigenetic therapy. Here we show that zebularine, a stable DNA cytosine methylation inhibitor, is preferentially incorporated into DNA and exhibits greater cell growth inhibition and gene expression in cancer cell lines compared to normal fibroblasts. In addition, zebularine preferentially depleted DNA methyltransferase 1 (DNMT1) and… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 53 REFERENCES

The p 21 inhibitorhuman cytidine deaminase

  • S. Waga, G. J. Hannon, D. Beach, B. Stillman
  • Cancer Chemother . Pharmacol .
  • 1994
Highly Influential
4 Excerpts

Cytotoxicity PCNA

  • L. H. Li, E. J. Olin, H. H. Buskirk, L. M. Reineke
  • Nature
  • 1970
Highly Influential
1 Excerpt

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