Preferential repair of DNA damage on the transcribed strand of the human metallothionein genes requires RNA polymerase II.

Abstract

To examine the possible role of transcription in directing repair of DNA damage in active genes, we compared repair of UV- and aflatoxin B1-induced damage on each strand of the human metallothionein (hMT) genes. Repair on the transcribed strand of an active hMT gene occurs at least 3 times faster than that on its nontranscribed strand. Both strands of… (More)

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@article{Leadon1991PreferentialRO, title={Preferential repair of DNA damage on the transcribed strand of the human metallothionein genes requires RNA polymerase II.}, author={Steven A. Leadon and Daniel A Lawrence}, journal={Mutation research}, year={1991}, volume={255 1}, pages={67-78} }