Preferential regulation of duplicated genes by microRNAs in mammals

  title={Preferential regulation of duplicated genes by microRNAs in mammals},
  author={Jingjing Li and G. Musso and Zhaolei Zhang},
  journal={Genome Biology},
  pages={R132 - R132}
Although recent advances have been made in identifying and analyzing instances of microRNA-mediated gene regulation, it remains unclear by what mechanisms attenuation of transcript expression through microRNAs becomes an integral part of post-transcriptional modification, and it is even less clear to what extent this process occurs for mammalian gene duplicates (paralogs). Specifically, while mammalian paralogs are known to overcome their initial complete functional redundancy through variation… CONTINUE READING
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