Corpus ID: 22857415

Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells.

  title={Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells.},
  author={Kia-Joo Puan and Chenggang Jin and H. Wang and Ghanashyam Sarikonda and Amy M. Raker and H. K. Lee and Megan I. Samuelson and E. Maerker-Hermann and Ljiljana Pasa-Tolic and E. Nieves and J. Giner and T. Kuzuyama and C. T. Morita},
  journal={International immunology},
  volume={19 5},
  • Kia-Joo Puan, Chenggang Jin, +10 authors C. T. Morita
  • Published 2007
  • Medicine
  • International immunology
  • Human Vgamma2Vdelta2 T cells are stimulated by prenyl pyrophosphates, such as isopentenyl pyrophosphate (IPP), and play important roles in mediating immunity against microbial pathogens and have potent anti-tumor activity. (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) has been identified as a metabolite in the 2-C-methyl-D-erythritol-4 phosphate (MEP) pathway for isoprenoid biosynthesis that is used by many bacteria and protozoan parasites. We find that HMBPP is the major… CONTINUE READING
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